When screening for new DHFR inhibitor molecules to treat bacterial infections, do you want the molecule to specifically target prokaryotic DHFR, eukaryotic DHFR, or both? Briefly explain your rationale.

When screening for new DHFR inhibitor molecules to treat bacterial infections, do you want the molecule to specifically target prokaryotic DHFR, eukaryotic DHFR, or both? Briefly explain your rationale.