What happens to the longevity of worms when RNAi is used to knockdown HIF-1 in MIT mutant worms?

Answer questions 1-4 by reading the following article. All answers must come from SOLELY from the following journal article . The answers should be 1-2 sentence and it should summarize the answers EFFECTIVELY and CONCISELY in 1-2 sentences unless specified otherwise. In question 1, you may use 4-5 sentences.

click on the link to access the article.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838777/

1. Explain the relevance of testing the phenotype of RNAi treatment for 400 genes on wild type or MIT mutant c. elegans .

2. What important discovery does this paper make about TAF-4 and HIF-1?

3. In worms, approximately how many genes does HIF-1 regulate during hypoxia?

4. What happens to the longevity of worms when RNAi is used to knockdown HIF-1 in MIT mutant worms?