Critically apprise the papers.

The topic is looking at a male adult patient with advance ALK positive non small cell cancer, does administration of crizotinib as a first line drug a good treatment to prevent disease prognosis and overall survival.

Task is to critically appraise some papers attached below. Need to write the overall finding , results and the good and the bads about each paper.

By looking at these paper, need to first critically appraise the papers than only at the end with one or two sentence answer the question if the medication is good for the treatment. I have found the papers just need to read and critically appraise them.

These paper as a focus and to critically appraise.
1. https://www.nejm.org/doi/full/10.1056/NEJMoa2027187

2.
https://www.oncotarget.com/article/15746/text/

3.
https://www.lungcancerjournal.info/article/S0169-5002(14)00520-0/fulltext