What is a business plan, for whom is it prepared, and why?

1. What is a business plan, for whom is it prepared,
and why?
2. What should a complete business plan include?
3. Who should prepare the business plan?
4. How is the plan used by potential investors, and what
are the four anchors they are attempting to validate?
5. What is a dehydrated business plan, and when and
why can it be an effective tool?
6. Explain the expression, “The numbers in the plan
don’t matter.”
7. How can entrepreneurs use the business plan process
to identify the best team members, directors, and
value-added investors?
8. Prepare an outline of a business plan tailored to the
specific venture you have in mind.

explain three potential factors that might foster dehumanization/de-individuation and lead to online aggressive behavior

Dehumanization has been defined as a denial of humanness to others and has been associated with aggression and a host of negative consequences (Moller & Deci, 2009). In contemporary society, the use of computer-based communications and social media outlets creates an open opportunity for people to be aggressive. For example, the increase of anonymity through technology has provided a medium for aggression. The current literature suggests that the power differential between the online aggressor and the victim is not considered enough (Bushman & Huesmann, 2010; Fiske, 2014). Both of these issues can lead to dehumanization.

For this Discussion, consider a situation in which aggressive behavior could occur online and think about how it might foster dehumanization.

a brief description of the situation you selected. Then explain three potential factors that might foster dehumanization/de-individuation and lead to online aggressive behavior. Finally, using a social psychology perspective, explain two ways online aggression could be reduced. Be specific and use the current literature to support your response.

Be sure to support your postings and responses with specific references to the Learning Resources.

How is a breach identified, and what are the steps a hospital or health care organization has to take to prevent a breach?

A data breach in health care can happen when information is stolen without the knowledge or authorization of the organization. The data is usually sensitive, confidential, or proprietary. Most of the time, this is a targeted attack by a cybercriminal.

How is a breach identified, and what are the steps a hospital or health care organization has to take to prevent a breach?
Locate an example of a hospital or health care organization that has suffered a security breach. Explain the security breach and the steps taken to mitigate the breach, and explain whether the steps taken were adequate, or if additional steps should have been taken.
Use APA style and 2 scholarly references within 5 years. 5-6 pages (excluding title page and reference page)

Would a bank reconciliation uncover this office fraud?

Harriet Knox, Ralph Patton, and Marcia Diamond work for a family physician, Dr. Gwen Contrad, who is in private practice. Dr. Contrad is knowledgeable about office management practices and has segregated the cash receipt duties as follows:

Knox opens the mail and prepares a triplicate list of money received.
She sends one copy of the list to Patton, the cashier, who deposits the receipts daily in the bank.
Diamond, the recordkeeper, receives a copy of the list and posts payments to the patients’ accounts.
About once a month the office clerks have an expensive lunch they pay for as follows:

First, Patton endorses a patient’s check in Dr. Contrad’s name and cashes it at the bank.
Knox then destroys the remittance advice accompanying the check.
Finally, Diamond posts payment to the customer’s account as a miscellaneous credit.
The three clerks justify their actions by their relatively low pay and the knowledge that Dr. Contrad will likely never miss the money.

Discussion Questions:
Who is the best person in Dr. Contrad’s office to reconcile the bank statement? Simply providing a name is insufficient; you have to explain why this person would be the best one to reconcile the bank statements. About 75 to 100 words are expected.
Would a bank reconciliation uncover this office fraud? Why or why not? Again, about 75-100 words are expected.

Write a memo to the NTFG giving them your vision of a gang-control project

Write a memo to the NTFG giving them your vision of a gang-control project. Would you take a hard-line approach and recommend that police employ anti-gang units that use tactics developed in the fight against organized crime families or a more liberal one by recommending the redevelopment of deteriorated neighborhoods in which gangs flourish? Make sure to cover all the bases in your report. Your report should be at least twp pages 12 font double spaced APA format.

Select a good and a poor example of coaching and explain the positive and negative effects of the styles.

Coaching and Sport. Select a good and a poor example of coaching and explain the positive and negative effects of the styles. 150 word minimum, please include your name, date, class, subject, professor’s name and any applicable references. Title information is not considered part of the word count.

Analyze and explain the challenges with freedom of speech.

Constitutional Rights

Research, review and analyze Korb v. Raytheon, 707 F.Supp. 63 (D.Mass. 1989). Based on your research and the case, write a 5-6 page paper in which you:

1.Analyze and evaluate each case independently by providing the following (about two paragraphs per case):

•Facts of the case

•Issues

•Rule

2.Analyze and explain the challenges with freedom of speech.

3.Analyze and explain any challenges with freedom of information.

4.Analyze and explain any challenges with employment law.

5.Analyze and discuss the public perceptions of Raytheon and its influence with the Department of Defense.

6.Analyze and discuss any fraud or misrepresentation on either side of the case.

7.Provide at least four (4) additional court cases that support your analysis

Appraise the key legislative drivers in relation to sustainable building, low carbon design and energy efficiency of buildings.

Assessment Rationale
Coursework aims:
Assessment for this module is based on the design of building services solutions for
domestic and commercial buildings and an ability to demonstrate the sustainability of
these solutions, whilst maintaining human comfort.
Students will look at a case study building in order to undertake this assessment.
In the report (1000 words), which should include text, drawings and calculations,
students design a simple services solution for a domestic building, including an
assessment of the energy performance of the building, drawings and a rationale
explaining their design. (LO1, LO2 and LO3)
This coursework addresses the module learning outcomes. Namely, by the end of
the module the successful student will be able to:
1. Appraise the key legislative drivers in relation to sustainable building, low carbon
design and energy efficiency of buildings. (KU)
2. Undertake energy and carbon assessments using standard metrics and software
and analyse the results of such assessments. (KU)
3. Evaluate the function and design of building services for a simple building, relating
to sustainability and human comfort. (KU)
Approved Document L1a plays a role in reducing CO
2
Emissions
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5CNMN005W Environmental Science 2021_22
Introduction to the Coursework
Requirements/Format
The coursework is an individual report, with a word count of 1000 words max and should
include text, drawings and calculations. Note. Drawings, tables and calculations will not
count towards your 1000 word count.
The coursework has a weighting of 25% towards your final module mark.
Key elements of the project will require in-depth research and proposals. These ‘key
elements’ are outlined below in the assessment criteria.
Note: It is important to support all of your proposals with an appropriate rationale.
You will be provided with drawings of a simple 2 storey domestic construction on
which your coursework is to be based.
You will also be provided with a model of the building in Design SAP which is a
software package that you will use to analyse the building’s energy performance.
Design SAP 2012 calculates the SAP rating, the environmental impact rating
(EIR), the dwelling emission rate (DER), the target emission rate (TER), the
dwelling fabric energy efficiency (DFEE) and the target fabric energy efficiency
(TFEE) as well as incorporating Elmhurst’s professional U-Value calculator.
https://www.elmhurstenergy.co.uk/software/sap-energy-software
The coursework requires you to propose 2 enhancements to the house which improve its
energy performance characteristics by reducing its operational energy demand.
Your 2 enhancements must be as follows:-
1. To improve the fabric of the building, supported by u-value calculations
2. To improve the heating of the building
You will evidence the improvements to the building through comparing the building
performance of the house you are given, with the one which incorporates your
enhancements.
Your report is to be presented with the following supporting information (as a minimum):-
1. A title page. – Not included in word count
Do NOT include your name or student number within the file name or anywhere
within your submission. The submission will be subject to anonymous marking.
Having logged into Turn-it-in on Blackboard, the system will record your
details anonymously and tutors will only see your name after the entire submission
has been assessed and provisional marks have been released to all students at the
same time.”
2. A contents page. – Not included in word count
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5CNMN005W Environmental Science 2021_22
3. A clear introduction setting out the performance characteristics of the house
before your suggested enhancements. This could commentary on information
such as:
a. the building’s use
b. it’s existing construction
c. the site and location
4. Proposals and rationale behind your 2 chosen enhancements including
demonstrating how they are compatible with the building’s existing or proposed
use, construction and location.
5. Supporting drawings and calculations should be of relevant technical details
complete with explanatory notes.
6. The report should be professionally presented, organised in a logical manner. It
should be easy to follow and to identify the main points.
7. The graphic material should add value, not confuse or have a neutral effect.
8. A conclusion, providing a clear summary of your proposals.
9. A list of references. Not included in word count.
10. The text is to be written with correct spelling, grammar and punctuation.

Is there a linkage between genetic factors and the risk of individuals developing Parkinson’s disease?

INTRODUCTION
Introduction to the Problem
Parkinson’s disease is a degenerative disease that causes motor and non-motor symptoms over time. Tremors, delayed movement, the rigidity of the arms and legs, and shaking arms are some of the most prevalent symptoms of the condition, which is regarded as the second most common neurological disease after Alzheimer’s. Parkinson’s disease symptoms usually start gradually and get worse over time. As the disease progresses, a person may experience mobility and communication issues (Postuma et al., 2015). In addition, mental and behavioral changes and sleep troubles, melancholy, memory loss, and lethargy may occur. Through its progressive degenerative effects on movement and muscular function, the disease has a significant clinical impact on patients, their family members, and caregivers. According to studies, three out of every thousand adults over the age of 50 suffer from the illness (Westenberger, 2012).
Background of the Problem
In 1817, Dr. James Parkinson first described PD as “shaking palsy” (Polymeropoulos, 1996). According to studies, pathophysiological changes linked to the disease may start before motor symptoms appear. They can involve a wide range of nonmotor symptoms, such as sleep problems, depression, and cognitive issues (Westenberger, 2012).
Diseases have appeared and disappeared throughout history, while some have risen or reduced in occurrence. Such epidemiological patterns have been more pronounced in infectious diseases (for example, the elimination of smallpox). Still, they have also been seen in chronic disorders (such as reducing vitamin deficiencies and cardiovascular disease). Changing patterns in the epidemiology of neurological illnesses have been observed during the last three or four decades. In several high-income countries, the incidence of stroke and dementia has reduced (specifically in North America and Western Europe). Nonetheless, the risk of Parkinson’s disease has risen (Rocca, 2017; Rocca, 2018).
In the United States, The Parkinson’s Disease Foundations reports that approximately 1 million Americans currently live with the illness (Westenberger, 2012). Parkinson’s disease is estimated to affect 20 people out of every 100,000 people each year, with a typical presentation age of 60 years. In persons 60 years and older, the prevalence of Parkinson’s disease is estimated to be around 1%, increasing from 1% to 3% in those aged 80 and above. It is, however, crucial to note that these figures do not represent undiagnosed cases.
The unpredictable but noticeable course of Parkinson’s disease substantially impacts individuals, families, and society. The advanced and end-stage illness can result in significant consequences, such as pneumonia, often fatal (Postuma et al., 2015). Even though current treatment focuses on symptom management, research suggests that patients benefit from a multidisciplinary approach to care. An interdisciplinary approach is movement experts, social workers, pharmacists, and other healthcare professionals.
PD is linked to several risk factors and genetic abnormalities. Oxidative stress, the generation of free radicals, and various environmental pollutants are risk factors for the disease. Although only limited data exist to support the genetic associations of Parkinson’s disease with gene mutations, the variable prevalence suggests that these factors may play a role in the pathogenesis of the illness (Redensek, 2017).
Statement of the Problem
The problem is that it has become clear that Parkinson’s disease is a complex genetically heterogeneous disorder (Polymeropoulos, 1996). To illustrate how complicated it is, we may talk about 28 distinctive chromosomal areas associated with PD. Just six of these regions contain genetic makeup with mutations that lead to monogenic PD, a type of disease in which a single gene mutation is enough to cause symptoms. Even when considered together, the mutation in these six genes is responsible for only 3–5% of all sporadic disease instances (Westenberger, 2012). Instead, the genesis of Parkinson’s disease is multifaceted and results from a complex interaction of commonly unidentified components, including multiple genes, susceptibility variants’ altering effects, environmental factors, and gene-environment interactions. Alterations (or mutations) in specific genes are passed down or transmitted from one generation to another in some families. Researchers are still puzzled why some ethnic groups, such as Ashkenazi and Northern Africa Arab Berbers, are more likely to possess genes associated with Parkinson’s disease (Day, 2021).
Purpose of the Study
It’s critical to understand the role of genetics as a risk factor for Parkinson’s disease. Understanding how Parkinson’s disease is linked to genetics will help us better understand how the disease develops and, ultimately, how this could be managed or cured. Such knowledge may assist doctors (1) in recognizing the genes that are linked to Parkinson’s disease, (2) in identifying the people who are most likely to develop Parkinson’s disease, (3) in providing a platform for the discovery of novel possible targets for neuroprotective therapy. Through genetic mapping, (4) to determine how accurate gene mapping is for Parkinson’s disease, (5) to establish whether genetic mapping can help figure out what caused the gene mutation and how the condition progressed, (6) to stratify PD patients based on their genetic fingerprint and tailor their therapy and supporting measures accordingly.
Research Question
This project aims to answer the following question: Is there a linkage between genetic factors and the risk of individuals developing Parkinson’s disease?
Significance of the Study
One way to divide Parkinson’s disease is through genetics. Aetiologies, therapies, and prognoses for different subgroups may differ. Age of onset (early- vs. late-onset PD, with a cut-off of 50 years of age), family history (familial vs. sporadic PD), and pathogenic variations (monogenic vs. idiopathic PD) are all common stratification criteria for Parkinson’s disease (Dumitriu, 2012; Redensek, 2017). Because the linkage between genetic factors and the risk of individuals developing PD has not been realized fully, this research will add to the body of knowledge of this understanding. This is because understanding the genetic factor of the disease will impact its mapping and clinical care.
To begin, the research will aid in identifying the causal genes and highlighting critical biological processes in pathogenesis. As revealed by the study conducted by Nalls et al. (2015), this will aid early diagnosis and indicate the disease’s prognosis. Initial non-motor indicators mixed with genetic susceptibility may be an excellent way to identify people in the early phases of the illness. Only genetic testing for sporadic PD diagnosis or prediction of sporadic PD development is not specific or sensitive enough at this time. No known genetic component or combination of genetic variables can predict the onset of sporadic PD with certainty.
Second, it can accurately classify the disease presentations into groups with common genetic origins. This is critical for ‘precision medicine,’ which focuses on a patient’s precise disease subtype. It would also be fascinating to examine the relationship between illness progression and genetic abnormalities in genes involved in various pathways. To illustrate, GBA mutations or MAPT H1 allele status could be independent risk factors for cognitive impairment in PD patients, and knowing these statuses in patients could affect therapy options (Lill, 2016). Patients have only been divided into groups based on their phenotypes thus far (Fereshtehnejad, 2015).
Different combinations of genetic abnormalities, on the other hand, should be investigated in order to develop a method for stratifying PD patients depending on the cumulative effects of genetic predisposition factors within and across pathways. Patients with different genetic abnormalities may require different treatment approaches; thus, stratifying Parkinson’s disease patients based on their underpinning genetic conditions could be beneficial in a therapeutic context. Because we can stratify patients into groups based on their impaired pathways and treat them based on their underlying pathologic processes, this type of tailored treatment could become the treatment of choice in the future for PD. Physicians could tweak therapy for each group to get the best potential result (Fereshtehnejad, 2015).
Finally, as we better understand the impact of genetic variations on disease risk, onset, and progression, the implications and prognosis may be addressed openly with individuals, empowering them to make informed decisions.
Assumptions
The following assumptions are made regarding this project. (1) The review of the literature was conducted by one author, therefore, risking bias during the research assessment; (2) The research question will elicit reliable responses as the study will involve quantitative methodology involving large populations; (3) There is a similarity in the participant characteristics within the study as the research involves participants who have Parkinson’s disease; (4) The study can be replicated since it uses a systematic approach to data collection, analysis, and synthesizing.
Limitations
The majority of the studies used in the literature review were conducted in the United States, and their findings do not reflect the conclusions of other populations around the world. The majority of studies focus on older people. Still, it is crucial to study midlife because it is a critical age for developing PD, with substantial individual heterogeneity and long-standing consequences in later life stages. The neurological system’s health specifically is impacted by lifestyle choices made around middle age. Excessive stress in middle age, for example, is linked to self-care incapacity later in life. In terms of PD-specific behavioral impacts, in midlife, a physically and cognitively active lifestyle is linked to a lower risk of illness. It can lower the risk of Parkinson’s disease by up to 40%. As a result, detecting Parkinson’s disease in middle age through mapping would offer patients the opportunity to take advantage of the neuroprotective capabilities of positive behavioral and environmental factors, particularly physical activity (Redensek, 2017).
Another critical limitation is the degree of epigenetic variations in patients that exceeds variance between populations and cell makeup of the examined tissue. To evaluate the most suitable individuals, standardization must be enhanced. Furthermore, reliable web resources that are not peer-reviewed were excluded since they caused coding and data analysis problems.
Summary
Parkinson’s disease (PD) is a neurodegenerative brain illness with a significant genetic component. Parkinson’s disease (PD) is the second most prevalent degenerative brain illness after Alzheimer’s disease. Parkinson’s disease is thought to be caused by a combination of hereditary and environmental factors. The disease’s current clinical diagnosis is based on late-stage motor symptoms when many nigrostriatal dopaminergic neurons have already been destroyed. The study will analyze the type of genes linked to Parkinson’s disease and whether gene mapping can be used in the early diagnosis and treatment of the disease.
The second chapter contains a review of previous research, including its history and current situation, which will support the stated public health issue. This chapter will thus give a detailed explanation of prior research conducted on genetic factors like a predisposition for PD. Chapter three comprises the systematic literature review methodology consisting of the description of the participants and their inclusion and exclusion criteria.

References
Day, J. O., & Mullin, S. (2021). The genetics of Parkinson’s disease and implications for clinical practice. Genes, 12(7), 1006.
Dumitriu, A. (2012). Genome-wide expression and genomic data integration analyses in sporadic Parkinson’s disease. Boston University.
Klein, C., & Westenberger, A. (2012). Genetics of Parkinson’s disease. Cold Spring Harbor Perspectives in Medicine, 2(1).
Lill, C. M. (2016). Genetics of Parkinson’s disease. Molecular and Cellular Probes, 30(6), 386-396.
Nalls, M. A., Pankratz, N., Lill, C. M., Do, C. B., Hernandez, D. G., Saad, M., … & Singleton, A. B. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. Nature Genetics, 46(9), 989-993.
Redenšek, S., Trošt, M., & Dolžan, V. (2017). Genetic determinants of Parkinson’s disease: Can they help to stratify the patients based on the underlying molecular defect? Frontiers in Aging Neuroscience, 9, 20.
Rocca, W. A. (2017). Time, sex, gender, history, and dementia. Alzheimer Disease and Associated Disorders, 31(1), 76.
Rocca, W. A. (2018). The future burden of Parkinson’s disease. Movement Disorders: Official Journal of the Movement Disorder Society, 33(1), 8.
Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., … & Deuschl, G. (2015). MDS clinical diagnostic criteria for Parkinson’s disease. Movement Disorders, 30(12), 1591-1601.
Polymeropoulos, M. H., Higgins, J. J., Golbe, L. I., Johnson, W. G., Ide, S. E., Di Iorio, G., … & Duvoisin, R. C. (1996). Mapping of a gene for Parkinson`s disease to chromosome 4q21-q23. Science, 274(5290), 1197-1199.

What are the major barriers preventing Asian populations from seeking mental health services?

METHODOLOGY
Introduction
This section provides the framework specific to how the systematic literature review was
conducted to answer the study’s research question. In addition, it describes the target groups of
the studies collected, as well as the methods that were used to gather the research articles.
Research Question
This project aims to answer the following research question: What are the major barriers
preventing Asian populations from seeking mental health services?
Description of the Participants
Research articles selected for the systematic literature review consisted of any population
of Asian descent living in a developed country. For example, Chinese immigrants, Japanese,
Filipino, Indonesian, Cambodian refugees, Indians, Malaysian, South Asian Immigrants in
Calgary, Taiwanese, Vietnamese Canadians, Thai, Laotian, and Korean (Americans) were
among those described in the study population. There were no other criteria used for selection of
target groups (e.g., age, profession, gender, education level).
Instrumentation
A systematic literature search was conducted in August 2016 on published studies
identifying barriers to utilizing mental health services among Asian subgroups living in North
America. Ten databases were used, including: PubMed, ProQuest Central, Academic Search
Premier, PsycARTICLES, Springer Standard Collection, CINAHL Plus with Full Text,
Psychology and Behavioral Sciences Collection, JSTOR Arts and Sciences VII, Sage Premier,
and ScienceDirect ArticleChoice. Boolean operators were used to create various search strings
with terms related to “barriers AND mental health services AND Asian*”.
Ethical Considerations
The study did not require Institutional Review Board (IRB) approval as the study was a
systematic literature review. To achieve the highest level of credibility when conducting the
review, only peer-reviewed, scholarly research articles were chosen for analysis.