Mistakes in protein folding are corrected by molecular chaperones, but there continues to be health disorders that result from mutations in protein primary sequence, such as sickle cell anemia. What other safeguards exist to assist in protein structure and function when there are undesirable alterations to a protein’s structure?

Mistakes in protein folding are corrected by molecular chaperones, but there continues to be health disorders that result from mutations in protein primary sequence, such as sickle cell anemia. What other safeguards exist to assist in protein structure and function when there are undesirable alterations to a protein’s structure?